Spain head coach Julen Lopetegui has allowed David Silva to leave the squad early due to personal reasons meaning the midfielder will miss the friendly against Argentina.
The 32-year-old has spent time away from his domestic club Manchester City following the premature birth of his son earlier this month.
Spain announced his departure via their Twitter on Saturday meaning he will not feature against Argentina at Atletico Madrid’s Wanda Metropolitano on Tuesday.
— Selección Española de Fútbol (@SeFutbol) March 24, 2018
The national team’s official Twitter account said: “Player David Silva has been released from the squad for personal reasons.”
He started in Friday’s 1-1 draw against reigning World Cup champions Germany before being replaced by Real Madrid’s Lucas Vasquez in the 71st minute.
Manchester City face Everton in the Premier League next Saturday before travelling to Anfield to face Liverpool in the first leg of their Champions League quarter-final tie.
Lopetegui is also waiting to assess whether centre-back Gerard Pique will be fit to play after sustaining a knock against Die Mannschaft and not being able to take part in training on Saturday.
While Sergio Ramos is also a doubt as he is waiting for the birth of his third child.
For Argentina, Barcelona star Lionel Messi is set to start against a team made up of many of his domestic teammates.