Real Madrid’s fixture with Valencia on Saturday night is expected not to feature Isco, who has reportedly fallen out with Santiago Solari.
The home side return to Madrid after sealing top spot in Group G of the Champions League after beating Roma 2-0 while Los Che exited the Champions League after defeat to Juventus.
Santiago Solari’s men have been woeful domestically this season, losing five from 13 matches, including a crushing 3-0 defeat at the hands of Eibar last weekend.
Despite that the Galacticos find themselves only six points behind leaders Sevilla, while a win here for the Bats will see them leapfrog their opponents on goal difference.
Valencia are currently on a five-match unbeaten away run whilst Madrid’s last win at home against the visitors came in 2008.
Marcelino’s men are on an upwards curve domestically and his much-improved side will be hoping to make in three wins on the bounce for the first time this season.
Madrid are slight favourites but will the problems between Isco and Solari trouble them even more this season?
The Spanish midfielder has played a larger part in Madrid’s side this term after the sale of Cristiano Ronaldo to Juventus last summer.
However, since Julen Lopetegui left the club following the 5-1 El Clasico defeat to Barcelona, Isco has seen less playing time.
The 26-year-old was an unused substitute against Roma on Tuesday evening, and it is now thought that his future at Madrid is being questioned.
Ever-linked with a move to Premier League side Manchester City, Isco is now expected to be shortlisted by Guardiola, who is a keen admirer of the midfielder.
City are favourites for the Premier League title, however, Guardiola wants to further enhance his side for a Champions League challenge and he could now make a move ready for next summer.
Former Malaga man Isco is said to be keen on a move to the Premier League, having been previously linked to City and Arsenal.