Barcelona are the only remaining La Liga side left in the Champions League after exits for Real Madrid and Atletico Madrid.
Two weeks ago, Barca were held by a resilient Lyon side to a 0-0 draw but following their recent form – Ernesto Valverde’s side are favourites to progress.
Barcelona will be hoping their profligacy from the first leg doesn’t come back to haunt them after not scoring from 25 attempts, but Lyon will know that they have scored in every home game this term.
Lyon will arrive confident, but away from home this season, they have lost their last three.
Rafinha is out for the season for the home side, while Ousmane Dembele and Thomas Vermaelen will be assessed ahead of Barcelona’s welcome of Lyon.
Should Dembele fail to prove his fitness, Coutinho could be handed another chance to impress on the left. Arturo Vidal and Arthur are competing for a starting spot alongside Ivan Rakitic and Sergio Busquets in midfield
For the visitors, Nabil Fekir is available following suspension, which is a huge boost for Lyon as they aim to upset the odds in Barcelona but they are sweating on the fitness of Rafael and Marcelo.
Barcelona: Ter Stegen, Roberto, Pique, Umtiti, Alba, Sergio Busquets, Vidal, Rakitic, Messi, Suarez, Coutinho
Lyon: Lopez, Dubois, Marcelo, Denayer, Mendy, Aouar, NDombele, Traore, Fekir, Depay, Dembele
2-1. Barcelona to edge it after a nervy start to the game which sees the French side score first.