Atletico Madrid will need a victory and a turn around in results to see them qualify for the last-32 of the Champions League.
Diego Simeone’s side find themselves on the brink of elimination after a chance to seal their first win of the competition two weeks ago against Tuesday night’s opponents.
Results elsewhere have not gone in favour of the Madrid based side, seeing both Chelsea and Roma sit first and second, respectively.
Just one win in five in all competitions for Atleti sees them head into the game with little confidence.
Qarabag manager Gurban Gurbanov is happy with his side’s progression in the competition and their draw with the former Champions League runners-up two weeks ago, and he will be hoping for a similar performance at the Wanda Metropolitano.
Only Koke and Yannick Carrasco are doubts for Simeone, but both are likely to recover in time and play some part.
The visitors have Badavi Guseinov, Tarik Elyounoussi, and Eltun Turabov unavailable through injury, whilst Dino Ndlovu is suspended after being sent off in the return game.
Expected Atletico Madrid starting eleven:
Oblak; Juanfran, Savic, Godin, Filipe Luis; Gabi, Augusto, Correa, Saul; Griezmann, Vietto
Expected Qarabag starting eleven:
Sehic; Medvedev, Sadygov, Guseynov, Agolli; Richard, Garayev; Henrique, Michel, Elyounoussi; Madatov