Barcelona and Real Madrid lost at the weekend and Atletico Madrid were beaten by bottom side Alaves last week.
Could it be a season outside of La Liga as the top three stumble in Spain?
They kept center back Jules Kunde and striker Yousef En-Nesiri in the summer and ensured quality with former Wölfen striker Rafa Mir and Tottenham’s Eric Lamela, two of the striking new arrivals.
The power in the depths is there with two top players for each position. If Lopetegui can make the team play as well as the quality of the team suggests, then why can’t they be at the top?
However, you have to believe. It’s been a while since they won the championship. You may never have had a better chance.
The last time they won the title was in 1946. They only won it once. You finished second four times, but not since 1957.
Unai Emery took over at the start of last season with one very clear goal – to win trophies. He won the club’s first silverware in the first season, so what’s his goal now?
At Villarreal you will be told everything is for four, but why not win the biggest prize when the Spanish football giants battle it out? They have a new form of hosting and competing with the biggest clubs in Europe.
Pau Torres had the best young defenders in Spain and Gerard Moreno had the greatest Spaniard last season. They have played too many games this season and are therefore in the middle of the table.
But former Bournemouth striker Arnaut Danjuma looks like one of the best new arrivals for the summer with four goals and if they turn a draw into a win, anything is possible.
Last time they won the title: they weren’t even in the top division before 1998. They never won the championship, but came 3rd in 2005 and 2nd in 2008.